| ncRNA name | PKCα siRNA |
| ncRNA Category | siRNA |
| Disease name | proliferative vitreoretinopathy (PVR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cells |
| Methods | siRNA transfection, RT-PCR, Western blot, immunofluorescence |
| Expression pattern | associated |
| Functional description | We previously found that downregulation of protein kinase Cα (PKCα) can inhibit retinal pigment epithelium (RPE) cell proliferation involved in the development of proliferative vitreoretinopathy (PVR). In this study, the results indicate that PKCα was significantly downregulated by siRNA-PKCα released from FCVB in human RPE cells and provide us with a new avenue to prevent PVR. |
| PubMed ID | 21753881 |
| Year | 2011 |
| Title | Protein kinase Cα downregulation via siRNA-PKCα released from foldable capsular vitreous body in cultured human retinal pigment epithelium cells. |
| Drug-related ncRNA | NO |
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